As vascular free radicals impinge on interstitial spaces, they spread a contagium that impairs the capillary cell’s outer membranes from fluxing their permeability. This blocks the criitcal feedback loop to their mitochondria to swing combustion to nitric oxide, in effect keeping mitochondrial fixed in energy mode. That fix, prevents the capillary cell from rejuvenation, causes a buildup of superoxide free radicals which accelerates DNA damage, which silences protein synthesis coding. All of this from a small particle LDL cholesterol, AGEs,…..