As vascular free radicals impinge on interstitial spaces, they spread a contagium that impairs the capillary cell’s outer membranes from fluxing their permeability. This blocks the criitcal feedback loop to their mitochondria to swing combustion to nitric oxide, in effect keeping mitochondrial fixed in energy mode. That fix, prevents the capillary cell from rejuvenation, causes a buildup of superoxide free radicals which accelerates DNA damage, which silences protein synthesis coding. All of this from a small particle LDL cholesterol, AGEs,…..
No other cell in the human body has evolved such a substantial array of switches, receptors, pores, slits, and diaphragms that co participate in the juggling of sequenced immune arsenal into interstitial spaces. Together with diffusion, facilitated diffusion and active transport these different membrane apparatus receive and send instructions. These come in the form of feedback loops to their mitochondria, nucleus and their interstitial space allies, as well to adjacent and distant endothelia and end organs. As they do this…..
Capillary cell outer membranes deploy an array of different receptors designed to attach choreographed immune arsenal into interstitial space staging areas for removal of inflammatory breach. Once attached, neutrophils, inducer T lymphocytes participate in one arm of breach containment while immunoglobulins and complement participate in the other arm. Together these two arms are used definitively to contain and eliminate breach through a process known as opsonization, where helper T lymphocytes, monocytes and macrophages engulf inflammatory residues and break them down…..
Karma is a word that resurfaced in the 1960s to connote a feeling or aura that is being projected by a person, place or experience. Karma is described as good or bad based upon perception and outcomes. So it is within the interstitial spaces of end organs. When the interstitial space is being protected by healthy capillary cells, the karma within the interstitial space is good and the end organ flourishes. When the space is being conflicted by chronic inflammation,…..
In every interstitial space of every end organ there is a war going on for control and ownership of the space and its contents. With aging, the war becomes increasingly biased to favor chronic inflammatoyr momentum in part due to increasing silence of capillary cell outer membrane receptors from increased free radical induced DNA cross linkage. Because of this bias, it becomes imperative for increasingly more stringent lifestyle adjustments and attention paid to insipid antioxidant and vitamin insufficiencies in order…..
The secret to anti-aging is to keep interstitial space sanitation optimal, which means limiting vascular inflammatory free radical penetration. Doing so enables capillary cell control of the interstitial space through their pivot and swing dance. If capillary mitochondria get stuck in energy combustion, chronic inflammation is winning the battle for interstitial space control and disease venues will pop-up. Aging, fatigue and pain follow. Do yourself a favor. Block vascular inflammatory free radical penetration into the interstitial space. Age with grace. See you…..
In my book Rejuvenation!, I reiterate that the exercise coefficient, which compares our capcoity to exercise maximally with what we should be able to do at age 25. This coefficient, not only measures skeletal muscle tone, but implies the extent to which our interstitial space sanitation has been optimized. When the coefficient in close to one, interstitial space hygiene is optimal which means the capillaries are dancing with great rhythm, chronic inflammation has been blocked, and disease venues such as…..
The key to anti-aging is preventing the influx of vascular inflammatory free radicals into interstitial spaces of end organs. This is accomplished through combinations of lifestyle decisions, supplements and medicinals. Doing so enables the continuation or return of the capillary cell dance which stems and paces homeostasis of the interstitial space and its allies-the mesenchymal cells, immune arsenal and end organ. The key to the capillary cell dance is the pivot and swing feedback loop relationship between capillary cell outer…..
The key to anti-aging is sanitizing the interstitial spaces of end organs. This becomes trickier as we age and requires a more intentional lifestyle effort as age related genetics and vitamin-antioxidant shortages cloud the sanitizing issue. To limit incomplete sanitation of interstitial spaces, vascular inflammatory free radical volumes must be kept low, meaning that lifestyle choices that increase them must be put to bed. If sanitizing can be optimized, the capillary cell pivot and swing dance will occur, which stems its…..
When it comes to lifestyle choices, by far the most misunderstood decisions are based on our knowledge of sugars. Even well intentioned decisions are often incorrectly made as processing and deceptive labeling preclude an accurate understanding. When in doubt, assume there is more sugar in the package than what is labeled. Make choices that are whole food plant abased.